Do you need more information
The VIDAS® Epstein-Barr Virus (EBV) panel provides a combination of three tests to rapidly confirm a diagnosis of Infectious Mononucleosis and clearly establish the stage of infection.
Do you need more information
Through detection of the main causative agent of Infectious Mononucleosis (IM), the VIDAS® EBV panel helps confirm a clinical diagnosis of the disease and rule out other pathologies which may produce IM-type symptoms. Rapid and clear diagnosis enables to reassure patients and physicians and avoid unnecessary investigations and treatment.
The panel includes three automated tests for the qualitative detection of anti-VCA IgM, anti-EBNA IgG and anti-VCA IgG/anti-EA IgG antibodies in human serum using the ELFA technique. Based on proprietary peptides, these assays are designed to provide the most relevant antibody responses to confidently define patient status.
VCA = Viral Capsid Antigen |
The VIDAS® EBV-specific tests are related to the time-dependent antibody response to various antigens produced during the Epstein-Barr Virus life cycle.
3 serological parameters - VCA IgM, VCA IgG and EBNA IgG – are necessary for EBV stage-specific diagnosis2,3:
* See resources for more information
** Diagnosis is established taking into account the age of the patient and the complete clinical picture.
Since 80% of patients yield EA IgG during acute IM, the combination of two markers in one test enables confirmation of the disease through earlier IgG detection.
References:
(1) Macsween KF and Crawford DH. Epstein-Barr virus – recent advances. Lancet Infectious Diseases. 2003;3:131-140.
(2) Hess RD, et al. Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still challenging after 35 years. J Clin Microbiology 2004;42:3381-3387.
(3) Lupo J, et al. Performance of Two Commercially Available Automated Immunoassays for the Determination of Epstein-Barr Virus Serological Status. Clin. Vaccine Immunol. 2012, 19(6):929. DOI: 10.1128/CVI.00100-12.
VIDAS® VCA IgM | VIDAS® VCA/EA IgG | VIDAS® EBNA IgG | |
---|---|---|---|
Reference | 30 237 | 30 236 | 30 235 |
Tests / kit | 30 | 30 | 30 |
Time to result | 40 minutes | 40 minutes | 40 minutes |
Sample type | Serum | Serum | Serum |
Sample volume | 100 µL | 100 µL | 100 µL |
Calibration frequency | Every 28 days | Every 28 days | Every 28 days |
Find more technical details on www.myvidas.com.
Consult your local bioMérieux representative for product availability in your country
The Monospot (or heterophile antibody) tests detect antibodies which, although not directed against EBV, are highly indicative of IM when present. Some have an excellent positive predictive value, but the method has limitations1,2:
|
=> A negative test cannot exclude IM. |
As a result, EBV serology is the method of choice for the diagnosis of IM.
References:
Infectious Mononucleosis: 10 Questions & Answers
Find more scientific and educational resources on www.myvidas.com.