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Fully adapted for emergency conditions, VIDAS® B.R.A.H.M.S. PCT™ aids physicians in making rational clinical decisions and allows optimized patient management. Results are available in only 20 minutes.
Procalcitonin has been demonstrated to:
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Procalcitonin (PCT) helps differentiate bacterial from viral infections, the early detection of an elevated PCT level in patients with suspected bacterial infections enabling earlier antibiotic treatment. PCT also supports informed decisions on when to continue or stop antibiotics, improving patient care and decreasing antibiotic misuse and resistance.
VIDAS® B.R.A.H.M.S PCT™ is an automated test for the determination of procalcitonin (PCT) in human serum or plasma.
Procalcitonin (PCT) is detected in the blood stream within 3 to 6 hours after an infectious challenge. It is upregulated in response to bacterial but not viral infections. The marker’s level rises with increasing severity of infection, and returns to normal as the infection resolves.
PCT has a half-life of 24 hours. In adults, levels decrease daily by around 50% if the bacterial infection is controlled by the immune system supported by effective antibiotic therapy. Non-decreasing levels may point to treatment failure.
Kinetic profiles of different biomarkers of bacterial infection - Click to enlarge
In clinical studies including more than 1,000 ICU patients it has been demonstrated that the application of a decision algorithm based on the relative decrease of plasma PCT levels over time allows a significant reduction in the duration of antibiotic therapy and the length of ICU stay, without apparent harm to patients with severe sepsis and septic shock2,3.
Procalcitonin-based algorithm for the decision to continue or stop antibiotics for patients
with sepsis in intensive care units - Click to enlarge
Due to the high specificity of PCT for bacterial infection, PCT measurement at relatively low concentrations can identify patients with clinically relevant bacterial infection of the lower respiratory tract (LRTI) who require antibiotic therapy6,7.
Data from multicenter randomized controlled trials in more than 1,000 patients with LRTI could demonstrate that with this approach, antibiotic exposure could be reduced by 65% in a primary care setting6. Importantly, there was no impairment of the patient outcome compared to standard treatment6.
It has been demonstrated that increased PCT values are the best indicator for the severity of infection and organ dysfunction8. As PCT levels correlate with severity of infection (as assessed by SOFA/Sequential Organ Failure Assessment score), an increase in PCT indicates progression of sepsis.
Choose VIDAS® B.R.A.H.M.S PCT™ to take advantage of key benefits:
References:
Technical specifications for VIDAS® B.R.A.H.M.S. PCT™
Reference | 30450 |
Tests / kit | 60 |
Sample type | Plasma (Lithium heparinate) or serum |
Sample volume | 200 uL |
Time to result | 20 minutes |
Measuring Range | 0.05 - 200ng/mL |
Calibration stability | 28 days |
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PCT Decisional Algorithm slide ruler
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